CAS 6746-94-7 Cyclopropylacetylene with high quality competitive price high customer satisfaction and safe fast delivery CAS NO.6746-94-7

    Yiwu Demei e-commerce firm is a dynamic and innovative enterprise, specializing in the research, manufacture and distribution of high-quality pharmaceutical ingredients and organic compounds. We are firmly committed to promoting the development of the global pharmaceutical industry and promoting the export of China's pharmaceutical products to the world. Our extensive product portfolio has been recognized in key markets. Adhering to the principle of honesty and transparency, we give priority to establishing a trustworthy relationship with customers to ensure the success and long-term cooperative partnership between the two sides.The company is located in Shijiazhuang, Hebei Province, the hub of Beijing-Tianjin-Hebei, and has more than ten years of industry experience. The affiliated factory covers an area of 7000 square meters. In addition, it also has its own excellent talent pool. Our high-tech R&D team has more than 200 R&D personnel in the workshop. In recent years, our products have been exported to Britain,Germany, Australia, the Netherlands, Poland, Russia, Kazakhstan, the Philippines, Malaysia, Singapore and many other regions. We do business with customers on the principle of honesty and trustworthiness. We are committed to satisfying our customers and gaining the greatest recognition from them within the scope permitted by law. We pay attention to every detail and strive to provide customers with the best services in procurement, research and development, quality control and safe transportation, so as to establish long-term cooperative relations with customers.

    The goal of our company is to become the best choice among pharmaceutical and chemical suppliers as soon as possible, with excellent product quality, in-place pre-sales and post-sales services, and safe and fast transportation and delivery. Therefore,as the company continues to develop, we will actively listen to opinions from all aspects. Comments and suggestions, participate in industry exchanges and learning, and strive to be an enterprise that keeps up with the trends of the times, produce, develop, and sell the latest products on the market, continue to grow and progress, and contribute a small amount to China's pharmaceutical and chemical trade.
 

Factory

    Our factory has a stable annual output of 50,000 tons of raw materials all year round. The production chain and sales chain continue to be saturated. Our warehouse has a large reserve of powder and liquid stocks. We welcome people from all walks of life to support and cooperate.

Packaging Details
Aluminum packages,carton box,wooden box,customized packaging
Warehouse:China
Delivery Detail
1.Delivery time:Within 3-15 days after the contracttakes effect

2.Delivery location:Address of the consignee(shouldbe the contracting unit)

3.Delivery method:We are responsible for thetransportation of the goods,FOB price

4.Freight method:air freight,ship freight
Payment Terms
Alibaba,Bitcoin,T/T,,Money Gram,Alipay and other remittance methods.

FAQ

1. Are you a manufacturer or a trader?We are an integrated company of industry and trade. We have our own factory and our own foreign trade department, with more than ten years of industry experience.
2.What is your minimum order quantity?
Different products have different minimum order quantities. Generally, the minimum order quantity is one kilogram of samples. For a few ultra-high value products, the minimum order quantity is 1g.
2.What are your payment methods?
Our payment methods include ,Money Gram,Alibaba,Alipay and T/T.
3.How long is your shipping time?
Under normal circumstances, the goods will be shipped on the same day or the next day after payment is made. It takes about three days for the goods to arrive at the freight forwarder. The international tracking number will be issued on the same day or the next day when the product arrives at the freight forwarder. Due to different countries, the transportation time also varies, which ranges from 7 to 25 days. , please consult customer service for specific time.
4.How can I get the samples?
For some products,we can provide you with free off the shelf samples.You just need to pay for delivery.

5. what services can we provide?
Since the products are mass-produced, customized products, customized purity, and customized packaging are not supported.

    Cyclopropylacetylene is a key intermediate of efavirenz, a special anti-AIDS drug. Efavelan is a non-nucleoside reverse transcriptase inhibitor, which can be used in highly active antiretroviral therapy to treat human immune virus HIVTypeI.
    Cyclopropylacetylene is often used as an intermediate in organic synthesis and medicinal chemistry, which can be used for the synthesis of drug molecules and bioactive molecules. For example, it is a key intermediate in the synthesis of efavirenz, a special anti-AIDS drug.

    Cyclopropylacethylene, also known as ethynyl cyclopropane, is a colorless or yellow transparent liquid at normal temperature and pressure. Cyclopropanethine belongs to alkynes, and the three-membered ring in the molecular structure is not stable because of the ring tension. In addition, the boiling point of this compound is low, so it needs to be concentrated at low temperature when preparing. Cyclopropylacetylene is often used as an intermediate in organic synthesis and medicinal chemistry, and can be used for the synthesis of drug molecules and bioactive molecules. For example, it is a key intermediate in the synthesis of Efavirenz, a specific anti-AIDS drug.

Preparation method
    Under the condition of stirring, methyl lithium (161.0 m L, 225.0 mmol of 1.4 M diethyl ether solution) was added dropwise to the tetrahydrofuran (300 mL) solution of α-(trichloromethyl) cyclopropyl methanol 4- methyl benzene sulfonate (50.0 mmol), and the temperature of the solution was slowly raised to zero, and the reaction was stirred at zero for more than one hour. After the reaction, the reaction was quenched with saturated ammonium chloride, the reaction solution was diluted with n-hexane, the two phases were separated, and the water phase was extracted with n-hexane (3 × 100m L). The combined organic layers were washed with brine for three times, dried with anhydrous Mg SO4, the organic extract was filtered, and the filtrate was concentrated in vacuum to obtain the target product molecules.

Organic synthesis and transformation
    In the organic synthesis and transformation, the carbon-hydrogen bond on the alkynyl group in cyclopropylacetylene has a certain acidity, which can be transformed into the corresponding alkynyl anion under the action of alkali; In addition, alkynes can react with NBS under the action of silver to introduce a bromine atom at the terminal position of alkynes; The ternary ring in the structure is prone to ring-opening reaction under the action of transition metals to obtain ring-opening linear products.

Experimental steps:
    N- bromosuccinimide (1.1 equivalent) and cyclopropylacetylene (1.0 equivalent) were dissolved in acetone in a round-bottomed flask, and then silver nitrate (0.10 mol%) was slowly added to the solution, and the obtained reaction mixture was stirred and reacted for 3 h at room temperature in the dark. After the reaction, the reaction mixture was concentrated under reduced pressure, and the crude product was filtered by short pad silica (pentane 100%) and separated and purified by column chromatography.